Hyman Vineyards News

Resveratrol Helps Keep the Heart Muscle Flexible and Healthy

A team of researchers led by Gary Meszaros and Joshua Bomser at the Northeastern Ohio Universities College of Medicine has shown that resveratrol not only inhibits production of endothelin-1, but also directly affects heart muscle cells to maintain heart health. Their research, published in the American Journal of Physiology: Heart and Circulatory Physiology, shows that resveratrol inhibits angiotensin II, a hormone that is secreted in response to high blood pressure and heart failure.

Angiotensin II has a negative effect on heart health in that it signals cardiac fibroblasts, the family of heart muscle cells responsible for secreting collagen, to proliferate. The result is the production of excessive amounts of collagen, which causes the heart muscle to stiffen, reducing its ability to pump blood efficiently.

In addition to inhibiting angiotensin II, and therefore the proliferation of cardiac fibroblasts, resveratrol also prevented the cardiac fibroblasts that were already present from changing into myofibroblasts, the type of cardiac fibroblast that produces the most collagen.